This research was supported in part by the University of Pittsburgh Organoid Research Core Facility, RRID:SCR_025698
2026
Neiswender, J.V., et. al. A dependency map enhanced with next-generation 3D cancer models. Nature, 2026 In Press.
Carleton, N. et. al. Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women. Nature Aging. July 17, 2026. https://www.nature.com/articles/s43587-026-01173-4
Foidart, P. et. al. Whole-genome doubling drives immune evasion by silencing antigen presentation. Cancer Cell. July 13, 2026. https://www.cell.com/cancer-cell/fulltext/S1535-6108(26)00218-7
Panesso-Gómez, S., et. al. Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer. Cancer Letters. May 28, 2026. https://www.sciencedirect.com/science/article/pii/S0304383526001989
Chang, H-C., et. al. Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner’s Guide. bioRxiv. 2026. https://doi.org/10.64898/2026.04.12.718050
Yang, Y. et. al. Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state. bioRxiv. 2026. https://www.biorxiv.org/content/10.64898/2026.01.15.699545v1
Hooda, J., et. al. Identification and Credentialing of Patient Derived Xenograft Models of Invasive Lobular Breast Carcinoma using Multi-omics and Histopathology assessment. bioRxiv. 2026.
Liu J. B., et. al. Dual HER2/HER3 Targeting with Antibody-Drug Conjugates Reveals a Novel Therapeutic Strategy for HER2-Mutant Lobular Breast Cancer. bioRxiv. 2026 https://www.biorxiv.org/content/10.64898/2026.06.18.733194v2
2025
Doerfler, R., et. al. Integrating artificial intelligence-driven digital pathology and genomics to establish patient-derived organoids as new approach methodologies for drug response in head and neck cancer. Oral Oncology 171, Dec. 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC13262258/
Møldrup R.I.J., et. al. SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer. Cancer Research. Dec. 1, 2025. https://aacrjournals.org/cancerres/article-abstract/85/23/4648/767290/SWI-SNF-Functions-as-a-Gatekeeper-of-Enhancer?redirectedFrom=fulltext
Chang, ACC., et. al. Hope for OTHERS (Our Tissue Helping Enhance Research & Science): research results from the University of Pittsburgh rapid autopsy program for breast cancer. Breast Cancer Res 27, 111, 2025.
Hu. D. et. al. p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2+ breast cancer that limits trastuzumab deruxtecan efficacy. Nature Cancer. Jun 27, 2025. https://www.nature.com/articles/s43018-025-00969-4
Jiang, Q., et. al. Role of the NuRD complex and altered proteostasis in cancer cell quiescence. bioRxiv. 2025. https://www.biorxiv.org/content/10.1101/2025.02.10.637435v1
Ma. Y., et. al. High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer. Analytical Chemistry. Mar 2025. https://pubs.acs.org/ancham/article/97/10/5498/3608885/High-Throughput-Empirical-and-Virtual-Screening-To
2024
Narayanan S. P., et. al. Transcriptomic analysis identifies enrichment of cAMP/PKA/CREB signaling in invasive lobular breast cancer. Breast Cancer Research. Oct 2024.